What are nucleotides and are they safe?

Nucleotide preparations approved for injection consist of highly purified, long-chain polynucleotides of natural origin. They are the building blocks of DNA, RNA but also of coenzymes – including coenzyme Q10 used for years in anti-ageing cosmetics. They are commonly found in nature.

The first uses of polynucleotides were in 1980. They have been registered for injection since 1990 – they were and still are used to promote wound healing.
The nucleotides used in our practice are manufactured in Italy by Promoitalia and have clinical studies and safety certificates allowing their use in the European Union.

How do nucleotides work?

Polynucleotides, unlike hyaluronic acid, penetrate into cells and stimulate the production of collagen and elastin. They also bind to the receptors on the cell surface – CD39 and CD40, which inhibits the formation of inflammatory mediators. Inflammation is known to be one of the main factors responsible for skin ageing. They influence fibroblast differentiation and have antioxidant properties – by trapping free radicals they are able to inhibit the ageing process. They have a water binding capacity. Among other things, they decompose into ATP which provides energy for the cells.

In practice, the following can be observed:

  • skin lifting
  • hydration
  • radiance
  • general improvement in the appearance of the skin (smoothness, skin density)

Nucleotides are also recommended for the treatment of scars and stretch marks

For whom?

For anyone who wants to inhibit or reverse the skin ageing process. Ideal for summer and for people living in cities, in polluted environments, due to its antioxidant action.

Which is better, nucleotides or Profhilo?

At present, it is too early to make a definitive assessment, but it seems that their action is complementary – hyaluronic acid, collagen and elastin are the 3 most important substances for the skin’s youthfulness. Perhaps a combined regimen will prove to be the most effective. Hyaluronic acid by itself is of course a stimulator of collagen synthesis, but not the strongest one – among the non-cross-linked (non-filler) hyaluronic acids, stabilised hyaluronic acid stands out positively, with a stronger effect in this respect than ordinary non-cross-linked hyaluronic acid.

Nucleotides, on the other hand, have different points of attachment and additional actions.

Treatment schedule

3-4 treatments every 2-4 weeks
In my practice regarding the facial oval, I only use nucleotides with the highest concentration of polynucleotides
They can be applied to the face or any area of the body

Recovery period

Side effects at the injection sites are: slight swelling, sometimes bruising, persistence of small palpable lumps for 2- 5 days.
Nucleotides are safe and are not an embolic material, unlike cross-linked hyaluronic acid.